A multiscale modeling approach to inflammation: A case study in human endotoxemia

نویسندگان

  • Jeremy D. Scheff
  • Panteleimon D. Mavroudis
  • Panagiota T. Foteinou
  • Gary An
  • Steve E. Calvano
  • John Doyle
  • Thomas E. Dick
  • Stephen F. Lowry
  • Yoram Vodovotz
  • Ioannis P. Androulakis
چکیده

Affiliations: a Department of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854 b Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 08854 c Department of Surgery, University of Chicago, Chicago, IL 60637 d Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08901 e Control and Dynamical Systems, California Institute of Technology, Pasadena, California 91125 f Department of Medicine, Case Western University, Cleveland, OH 44106 g Department of Surgery, University of Pittsburgh, PA 15213 h Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219 # Present address: Department of Biomedical Engineering and the Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, USA

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Investigation of Vacancy Defects on the Young’s Modulus of Carbon Nanotube Reinforced Composites in Axial Direction via a Multiscale Modeling Approach

In this article, the influence of various vacancy defects on the Young’s modulus of carbon nanotube (CNT) - reinforcement polymer composite in the axial direction is investigated via a structural model in ANSYS software. Their high strength can be affected by the presence of defects in the nanotubes used as reinforcements in practical nanocomposites. Molecular structural mechanics (MSM)/finite ...

متن کامل

TRANSLATIONAL PHYSIOLOGY Multiscale model for the assessment of autonomic dysfunction in human endotoxemia

Foteinou PT, Calvano SE, Lowry SF, Androulakis IP. Multiscale model for the assessment of autonomic dysfunction in human endotoxemia. Physiol Genomics 42: 5–19, 2010. First published March 16, 2010; doi:10.1152/physiolgenomics.00184.2009.—Severe injury and infection are associated with autonomic dysfunction. The realization that a dysregulation in autonomic function may predispose a host to exc...

متن کامل

Multiscale model for the assessment of autonomic dysfunction in human endotoxemia.

Severe injury and infection are associated with autonomic dysfunction. The realization that a dysregulation in autonomic function may predispose a host to excessive inflammatory processes has renewed interest in understanding the role of central nervous system (CNS) in modulating systemic inflammatory processes. Assessment of heart rate variability (HRV) has been used to evaluate systemic abnor...

متن کامل

Dynamics of Macro–Nano Mechanical Systems; Fixed Interfacial Multiscale Method

The continuum based approaches don’t provide the correct physics in atomic scales. On the other hand, the molecular based approaches are limited by the length and simulated process time. As an attractive alternative, this paper proposes the Fixed Interfacial Multiscale Method (FIMM) for computationally and mathematically efficient modeling of solid structures. The approach is applicable to mult...

متن کامل

Modelling the Dynamics of Human Resources Capacity in Health Care Services A Case Study of Khatam-al-Anbia Hospital of Mashhad

Background: In service organizations such as hospitals, human resources (HR) play a key role in the quality of service delivery. Lack of a systemic attitude in terms of system dynamics, HR planning have been somewhat distant from reality. In order to solve such a problem, this study aimed to modeling the dynamics of human resources capacity management system in healthcare services.   Material...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • J. Comput. Physics

دوره 244  شماره 

صفحات  -

تاریخ انتشار 2013